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TAINER, JOHN
One or more keywords matched the following items that are connected to TAINER, JOHN
Item TypeName
Concept Binding Sites
Concept Binding Sites, Antibody
Academic Article Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS.
Academic Article Mechanism and atomic structure of superoxide dismutase.
Academic Article Probing the structural basis for enzyme-substrate recognition in Cu,Zn superoxide dismutase.
Academic Article Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c.
Academic Article Metal-binding sites in proteins.
Academic Article Protein metal-binding sites.
Academic Article Altering the antigenicity of proteins.
Academic Article Defining antibody-antigen recognition: towards engineered antibodies and epitopes.
Academic Article Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket.
Academic Article Metalloantibodies.
Academic Article Enzyme motifs in antibodies.
Academic Article Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase.
Academic Article The chemistry and mechanism of antibody binding to protein antigens.
Academic Article Structure and mechanism of copper, zinc superoxide dismutase.
Academic Article Electrostatic recognition between superoxide and copper, zinc superoxide dismutase.
Academic Article Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.
Academic Article Predicting molecular interactions and inducible complementarity: fragment docking of Fab-peptide complexes.
Academic Article Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA.
Academic Article Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase.
Academic Article Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.
Academic Article Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.
Academic Article Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain.
Academic Article Enzyme structure. Cracking tyrosine phosphatases.
Academic Article The role of arginine 143 in the electrostatics and mechanism of Cu,Zn superoxide dismutase: computational and experimental evaluation by mutational analysis.
Academic Article Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel.
Academic Article Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.
Academic Article Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase.
Academic Article A mutation in the human cyclin-dependent kinase interacting protein, CksHs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly.
Academic Article Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits.
Academic Article Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.
Academic Article Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
Academic Article Atomic and residue hydrophilicity in the context of folded protein structures.
Academic Article Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase.
Academic Article Rational design and expression of a heparin-targeted human superoxide dismutase.
Academic Article Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Academic Article The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Academic Article The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.
Academic Article Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34.
Academic Article Probing the active site of human manganese superoxide dismutase: the role of glutamine 143.
Academic Article Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase.
Academic Article Screening a peptidyl database for potential ligands to proteins with side-chain flexibility.
Academic Article Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase.
Academic Article Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex.
Academic Article Role of tryptophan 161 in catalysis by human manganese superoxide dismutase.
Academic Article Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
Academic Article Mutation of an active site residue in Escherichia coli uracil-DNA glycosylase: effect on DNA binding, uracil inhibition and catalysis.
Academic Article Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase.
Academic Article Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Academic Article Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products.
Academic Article Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1.
Academic Article Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase.
Academic Article Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis.
Academic Article Exon 5 encoded domain is not required for the toxic function of mutant SOD1 but essential for the dismutase activity: identification and characterization of two new SOD1 mutations associated with familial amyotrophic lateral sclerosis.
Academic Article Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.
Academic Article Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
Academic Article Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Academic Article Crystal structure and novel recognition motif of rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: structural insights for recognition specificity and catalysis.
Academic Article Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.
Academic Article N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
Academic Article Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis.
Academic Article Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase.
Academic Article Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means.
Academic Article Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.
Academic Article Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases.
Academic Article MDB: the Metalloprotein Database and Browser at The Scripps Research Institute.
Academic Article Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase.
Academic Article Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Academic Article The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.
Academic Article The ARTT motif and a unified structural understanding of substrate recognition in ADP-ribosylating bacterial toxins and eukaryotic ADP-ribosyltransferases.
Academic Article Structural basis for endothelial nitric oxide synthase binding to calmodulin.
Academic Article Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures.
Academic Article Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
Academic Article Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel.
Academic Article Structural basis for recognition and catalysis by the bifunctional dCTP deaminase and dUTPase from Methanococcus jannaschii.
Academic Article Identification of a new cryptochrome class. Structure, function, and evolution.
Academic Article Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum.
Academic Article ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization.
Academic Article The rad50 signature motif: essential to ATP binding and biological function.
Academic Article Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
Academic Article Nickel superoxide dismutase structure and mechanism.
Academic Article Amino acid substitution at the dimeric interface of human manganese superoxide dismutase.
Academic Article Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.
Academic Article Interaction interface of human flap endonuclease-1 with its DNA substrates.
Academic Article Role of hydrogen bonding in the active site of human manganese superoxide dismutase.
Academic Article DNA binding and nucleotide flipping by the human DNA repair protein AGT.
Academic Article Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase.
Academic Article Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine.
Academic Article A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.
Academic Article WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Academic Article Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.
Academic Article Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV.
Academic Article The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase.
Academic Article Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease.
Academic Article The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.
Academic Article DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.
Academic Article Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes.
Academic Article p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses.
Academic Article Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
Academic Article Substrate recognition and catalysis by flap endonucleases and related enzymes.
Academic Article ATP induces conformational changes in the carboxyl-terminal region of ClC-5.
Academic Article The structure of the CRISPR-associated protein Csa3 provides insight into the regulation of the CRISPR/Cas system.
Academic Article Mapping interactions between the RNA chaperone FinO and its RNA targets.
Academic Article Archaeal flagellar ATPase motor shows ATP-dependent hexameric assembly and activity stimulation by specific lipid binding.
Academic Article ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.
Academic Article The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.
Academic Article Solution structure of RNase P RNA.
Academic Article Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions.
Academic Article Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily.
Academic Article Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants.
Academic Article Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
Academic Article Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.
Academic Article Kinetic and stoichiometric characterisation of streptavidin-binding aptamers.
Academic Article Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2.
Academic Article Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing.
Academic Article FlaF Is a ?-Sandwich Protein that Anchors the Archaellum in the Archaeal Cell Envelope by Binding the S-Layer Protein.
Academic Article Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus.
Academic Article Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.
Academic Article Hybrid Methods Reveal Multiple Flexibly Linked DNA Polymerases within the Bacteriophage T7 Replisome.
Academic Article Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Academic Article Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
Academic Article Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.
Academic Article X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology.
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